Article

Rhodopsin moonlights as a tunable capacitor buffering the toxic, desensitizing retinoids of the vertebrate eye

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> The eye is a marvel of evolution, but visual sensitivity introduces the risk of blinding photodamage. Here we reveal that the locus of sensitivity—the visual pigment rhodopsin —moonlights as a tunable mechanism of retinal photoprotection. Independent of signaling, light activated rhodopsin (R*) serves as an overflow capacitor buffering all- trans retinal (atRAL), a toxic and desensitizing retin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac8ac771-b3af-542a-84ad-025cd50ae45d
DOI: 10.64898/2026.05.05.722510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rhodopsin moonlights as a tunable capacitor buffering the toxic, desensitizing retinoids of the vertebrate eyeDOI 10.64898/2026.05.05.722510Read

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Semantic proximity Read

Constitutively active rhodopsin and retinal disease.Semantic proximity Read

ER stress in retinal degeneration: a target for rational therapy?Semantic proximity Read

Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa.Semantic proximity Read

Synchronized photoactivation of T4K rhodopsin causes a chromophore-dependent retinal degeneration that is moderated by interaction with phototransduction cascade componentsSemantic proximity Read

Pathways and disease-causing alterations in visual chromophore production for vertebrate visionSemantic proximity Read

Rhodopsin: structure, function, and genetics.Semantic proximity Read

An experimental comparison of human and bovine rhodopsin provides insight into the molecular basis of retinal disease.Semantic proximity Read

Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategiesSemantic proximity Read

Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue.Semantic proximity Read

A synthetic opsin restores vision in patients with severe retinal degeneration.Semantic proximity Read

The eye photoreceptor protein rhodopsin. Structural implications for retinal disease.Semantic proximity Read