Article

Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

2022-04-08

Abstract excerpt

<h4>ABSTRACT</h4> The correct expression of folded, functional rhodopsin (Rho) is critical for visual perception. However, this seven-transmembrane helical G protein-coupled receptor (GPCR) is prone to mutations with pathological consequences of retinal degeneration in retinitis pigmentosa (RP) due to Rho misfolding. Pharmacological chaperones that stabilize the inherited Rho variants by assisting their folding a...

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Literature Corpus work: dc1db472-47d7-5428-bcb3-3daf05f9886f
DOI: 10.1101/2022.04.05.487228

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