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Article

<i>KIBRA</i>gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia

1 Mar 2012

Abstract excerpt

Ras-association domain family (RASSF) members are a family of genes containing an RA domain in either the C-terminus (RASSF1-RASSF6) or in the N-terminus (RASSF7-RASSF10). Members of this gene family are core members of the Salvador/Warts/Hippo (SWH) tumor suppressor network and have been shown to be involved in human tumorigenesis. Among the RASSF genes, RASSF1A is one of the most frequently methylated genes in...

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PMID: 22430796
DOI: 10.4161/epi.7.3.19222

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