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Article

Methylation markers identify high risk patients in IGHV mutated chronic lymphocytic leukemia.

Epigenetics - 1 Mar 2011

Irving Laura, Mainou-Fowler Tryfonia, Parker Anton, Ibbotson Rachel E, Oscier David G, Strathdee Gordon

Abstract excerpt

Chronic lymphocytic leukemia (CLL) exhibits a very variable clinical course. Altered DNA methylation of genes has shown promise as a source of novel prognostic makers in a number of cancers. Here we have studied the potential utility of a panel of methylation markers (CD38, HOXA4 and BTG4) in 118 CLL patients. Each of the three loci assessed exhibited frequent methylation, as determined by COBRA analysis, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21051931
DOI: 10.4161/epi.6.3.14038
PMCID: PMC3092678

Genes

BTG4
HOXA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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