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Article

Cytokinergic IgE Action in Mast Cell Activation

1 Jan 2012

Abstract excerpt

Some 10 years ago it emerged that at sufficiently high concentrations certain monoclonal mouse IgEs exert previously unsuspected effects on mast cells. Thus they can both promote survival and induce activation of mast cells without the requirement for antigens. This was a wake up call that appears to have been missed (or dismissed) by the majority of immunologists. The structural attributes responsible for the...

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PMID: 22888332
DOI: 10.3389/fimmu.2012.00229

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