Article
FcεRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcεRIβ chain.
Biochemical and biophysical research communications - 15 Jul 2011
Terada Tomoyoshi, Nunomura Satoshi, Shimokawa Toshibumi, Murayama Koichi, Era Seiichi, Kondo Naomi, Ra Chisei
Abstract excerpt
The high affinity IgE Fc receptor (FcεRI) β chain is well implicated as a signal amplifier through the immunoreceptor tyrosine-based activation motif (ITAM) in its C-terminal intracellular region. Our previous study, however, demonstrated that mutation in all of the three tyrosine residues within the FcεRIβ ITAM did not impair FcεRI-induced cytokine production, suggesting a possible functional region other than...
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