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Article

FcεRIγ-ITAM Is Differentially Required for Mast Cell Function In Vivo

1 Feb 2004

Abstract excerpt

The cross-linking of IgE-bound FcepsilonRI by Ags triggers mast cell activation leading to allergic reactions. The in vivo contribution of FcepsilonRIgamma signaling to IgE/FcepsilonRI-mediated mast cell responses has not yet been elucidated. In this study FcepsilonRIgamma(-/-) mast cells were reconstituted with either wild-type or mutant FcepsilonRIgamma in transgenic mice and transfected mast cells in vitro. We...

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Identifiers

PMID: 14764707
DOI: 10.4049/jimmunol.172.4.2374

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