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Article

Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum.

Gut - 1 Jun 2012

Yamauchi Mai, Morikawa Teppei, Kuchiba Aya, Imamura Yu, Qian Zhi Rong, Nishihara Reiko, Liao Xiaoyun, Waldron Levi, Hoshida Yujin, Huttenhower Curtis, Chan Andrew T, Giovannucci Edward, Fuchs Charles, Ogino Shuji

Abstract excerpt

OBJECTIVE: Colorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour location. Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that tumour molecular features might gradually change along bowel subsites, rather than change abruptly at splenic flexure. DESIGN:...

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Identifiers

PMID: 22427238
DOI: 10.1136/gutjnl-2011-300865
PMCID: PMC3345105

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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