Article
Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.
Journal of gastroenterology - 1 Mar 2023
Ugai Tomotaka, Akimoto Naohiko, Haruki Koichiro, Harrison Tabitha A, Cao Yin, Qu Conghui, Chan Andrew T, Campbell Peter T, Berndt Sonja I, Buchanan Daniel D, Cross Amanda J, Diergaarde Brenda, Gallinger Steven J, Gunter Marc J, Harlid Sophia, Hidaka Akihisa, Hoffmeister Michael, Brenner Hermann, Chang-Claude Jenny, Hsu Li, Jenkins Mark A, Lin Yi, Milne Roger L, Moreno Victor, Newcomb Polly A, Nishihara Reiko, Obon-Santacana Mireia, Pai Rish K, Sakoda Lori C, Schoen Robert E, Slattery Martha L, Sun Wei, Amitay Efrat L, Alwers Elizabeth, Thibodeau Stephen N, Toland Amanda E, Van Guelpen Bethany, Zaidi Syed H, Potter John D, Meyerhardt Jeffrey A, Giannakis Marios, Song Mingyang, Nowak Jonathan A, Peters Ulrike, Phipps Amanda I, Ogino Shuji
Abstract excerpt
BACKGROUND: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those related to microbiota, inflammation, metabolism, and epigenetics, which may change along colorectal segments. We hypothesized that the prognostic association of colon cancer location might differ by tumor molecular characteristics. METHODS: Utilizing a consortium dataset of 13,101...
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