Article
Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene.
The pharmacogenomics journal - 1 Jun 2013
Chowdhury N I, Tiwari A K, Souza R P, Zai C C, Shaikh S A, Chen S, Liu F, Lieberman J A, Meltzer H Y, Malhotra A K, Kennedy J L, Müller D J
Abstract excerpt
Antipsychotic-induced weight gain (AIWG) may result in the metabolic syndrome in schizophrenia (SCZ) patients. Downstream variants of the melanocortin-4 receptor (MC4R) gene have been associated with obesity in various populations. Thus, we examined single-nucleotide polymorphisms (SNPs) in the MC4R region for association with AIWG in SCZ patients. Four SNPs (rs2229616, rs17782313, rs11872992 and rs8087522) were...