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Article

Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment.

Journal of clinical psychopharmacology - 1 Dec 2010

Perez-Iglesias Rocio, Mata Ignacio, Amado Jose Antonio, Berja Ana, Garcia-Unzueta Maria Teresa, Martínez García Obdulia, Arranz Maria Jesús, Vazquez-Barquero Jose Luis, Crespo-Facorro Benedicto

Abstract excerpt

Weight gain is one of the major adverse effects of antipsychotics. Although mechanisms remain unclear, genetic susceptibility has become increasingly attractive as a potential mechanism that could explain a significant part of interindividual variability. Most investigations have explored genes related with the mechanism of action of antipsychotic drugs. An alternative approach to investigate the role that...

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Share to Adaptor Proteins, Signal Transducing
Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21105276
DOI: 10.1097/jcp.0b013e3181fae248

Genes

FTO
LEP
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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