Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample.

doi:10.2217/pgs.10.50

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Article

Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample.

Pharmacogenomics - 1 Jun 2010

Opgen-Rhein Carolin, Brandl Eva Janina, Müller Daniel J, Neuhaus Andres H, Tiwari Arun K, Sander Thomas, Dettling Michael

Abstract excerpt

BACKGROUND: Drug-induced bodyweight gain (BWG) is a serious concern in pharmacotherapy with second-generation antipsychotics. The interindividual variability is likely to be modulated by genetic factors. In the past, pharmacogenetic studies yielded conflicting results, and none of the identified genetic alterations exerts sufficient predictive value for this severe side effect of psychopharmacotherapy. AIM: We...

Topics

Adolescent
Adult
Aged
Alleles
Antipsychotic Agents
Case-Control Studies
Female
Genes, X-Linked
Genotype
Germany
Humans
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leptin

Logistic Models

Male

Membrane Proteins

Middle Aged

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 20504252
DOI: 10.2217/pgs.10.50

Genes

INSIG2
LEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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