Article
Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples.
Experimental and molecular pathology - 1 Jun 2012
Didelot Audrey, Le Corre Delphine, Luscan Armelle, Cazes Aurélie, Pallier Karine, Emile Jean-François, Laurent-Puig Pierre, Blons Hélène
Abstract excerpt
BACKGROUND: The development of targeted therapies has created a need for robust molecular characterization of cancer and it has become a challenge to validate methods to ensure accuracy in tumor mutation testing. METHODS: The current study was designed to evaluate KRAS, BRAF and EGFR genotyping by Competitive Allele Specific hydrolysis probes (TaqMan) PCR technology (CAST), on suboptimal formalin fixed paraffin...
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