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Article

KRAS mutation analysis by PCR: a comparison of two methods.

PloS one - 1 Jan 2015

Bolton Louise, Reiman Anne, Lucas Katie, Timms Judith, Cree Ian A

Abstract excerpt

BACKGROUND: KRAS mutation assays are important companion diagnostic tests to guide anti-EGFR antibody treatment of metastatic colorectal cancer. Direct comparison of newer diagnostic methods with existing methods is an important part of validation of any new technique. In this this study, we have compared the Therascreen (Qiagen) ARMS assay with Competitive Allele-Specific TaqMan PCR (castPCR, Life Technologies)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25568935
DOI: 10.1371/journal.pone.0115672
PMCID: PMC4287618

Genes

KRAS
BRAF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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