The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).

doi:10.1016/j.yexcr.2020.111927

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The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).

Experimental cell research - 1 May 2020

En Atsuki, Takauji Yuki, Ayusawa Dai, Fujii Michihiko

Abstract excerpt

Cellular senescence is a phenomenon of irreversible growth arrest of mammalian somatic cells. Senescent cells increase the production of secretory proteins such as inflammatory cytokines, a phenomenon termed senescence-associated secretory phenotype (SASP). SASP is known to have profound effects on organismal health and aging; however, the molecular mechanisms of SASP are not precisely understood. In our previous...

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Cellular Senescence
HeLa Cells
Heterochromatin
Interleukin-6
Interleukin-8
Matrix Metalloproteinase 1
Receptors, Cytoplasmic and Nuclear

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PMID: 32126237
DOI: 10.1016/j.yexcr.2020.111927

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