Article
Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin.
The Journal of investigative dermatology - 1 Aug 2015
Waldera Lupa Daniel M, Kalfalah Faiza, Safferling Kai, Boukamp Petra, Poschmann Gereon, Volpi Elena, Götz-Rösch Christine, Bernerd Francoise, Haag Laura, Huebenthal Ulrike, Fritsche Ellen, Boege Fritz, Grabe Niels, Tigges Julia, Stühler Kai, Krutmann Jean
Abstract excerpt
Most molecular hallmarks of cellular senescence have been identified in studies of cells aged in vitro by driving them into replicative or stress-induced senescence. Comparatively, less is known about the characteristic features of cells that have aged in vivo. Here we provide a systematic molecular analysis of normal human dermal fibroblasts (NHDFs) that were isolated from intrinsically aged human skin of young...
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