Article
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.
Annals of the rheumatic diseases - 1 Apr 2011
Bossini-Castillo Lara, Broen Jasper C A, Simeon Carmen P, Beretta Lorenzo, Vonk Madelon C, Ortego-Centeno Norberto, Espinosa Gerard, Carreira Patricia, Camps María Teresa, Navarrete Nuria, González-Escribano María F, Vicente-Rabaneda Esther, Rodríguez Luis, Tolosa Carlos, Román-Ivorra José A, Gómez-Gracia Inmaculada, García-Hernández Francisco J, Castellví Iván, Gallego María, Fernández-Nebro Antonio, García-Portales Rosa, Egurbide María Victoria, Fonollosa Vicente, de la Peña Paloma García, Pros Ana, González-Gay Miguel A, Hesselstrand Roger, Riemekasten Gabriela, Witte Torsten, Coenen Marieke J H, Koeleman Bobby P, Houssiau Frederic, Smith Vanessa, de Keyser Filip, Westhovens Rene, De Langhe Ellen, Voskuyl Alexandre E, Schuerwegh Annemie J, Chee Meng May, Madhok Rajan, Shiels Paul, Fonseca Carmen, Denton Christopher, Claes Kathleen, Padykov Leonid, Nordin Annika, Palm Oyvind, Lie Benedicte A, Airó Paolo, Scorza Raffaella, van Laar Jacob M, Hunzelmann Nicolas, Kreuter Alexander, Herrick Ariane, Worthington Jane, Radstake Timothy R D J, Martín Javier, Rueda Blanca
Abstract excerpt
OBJECTIVES: The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. METHODS: A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, and ) were selected as genetic...