Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder.

International journal of psychiatry in clinical practice - 1 Oct 2012

Vulink Nienke C C, Westenberg Herman G M, van Nieuwerburgh Filip, Deforce Dieter, Fluitman Sjoerd B A H A, Meinardi Jantien S C, Denys Damiaan

Abstract excerpt

OBJECTIVE: To determine whether polymorphisms of the dopamine D(2) receptor (DRD2) and catechol-O-methyl-transferase (COMT) receptor genes affect the efficacy of quetiapine addition to citalopram in patients with OCD. METHODS: Sixty-four drug-free or drug-naïve patients meeting DSM-IV criteria for OCD were randomized to 10 weeks double-blind treatment with citalopram (60 mg/day) with quetiapine (300 -450 mg/day)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Citalopram

Share to Double-Blind Method

Share to Drug Therapy, Combination

Share to Obsessive-Compulsive Disorder

Share to Receptors, Dopamine D2

Share to Selective Serotonin Reuptake Inhibitors

Source

Identifiers

PMID: 22414277
DOI: 10.3109/13651501.2011.653375

Genes

COMT
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder.PMID 22414277Read ↗

Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapySemantic proximity Read ↗

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.Semantic proximity Read ↗

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.Semantic proximity Read ↗

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.Semantic proximity Read ↗

Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder.Semantic proximity Read ↗

Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.Semantic proximity Read ↗

Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment.Semantic proximity Read ↗

Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males.Semantic proximity Read ↗

Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele.Semantic proximity Read ↗

Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.Semantic proximity Read ↗

Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients.Semantic proximity Read ↗

Interaction between angiotensin-converting enzyme and catechol-O-methyltransferase genotypes in schizophrenics with poor response to conventional neuroleptics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.