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Article

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.

Human psychopharmacology - 1 Sept 2015

Umehara Hidehiro, Numata Shusuke, Tajima Atsushi, Kinoshita Makoto, Nakaaki Shutaro, Imoto Issei, Sumitani Satsuki, Ohmori Tetsuro

Abstract excerpt

OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity. The purpose of the present study was to investigate whethe...

Read the complete abstract on PubMed

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Share to Antipsychotic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 26010653
DOI: 10.1002/hup.2485

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26010653-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.PMID 26010653Read ↗

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