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Article

Ensemble Models of Neutrophil Trafficking in Severe Sepsis

8 Mar 2012

Abstract excerpt

A hallmark of severe sepsis is systemic inflammation which activates leukocytes and can result in their misdirection. This leads to both impaired migration to the locus of infection and increased infiltration into healthy tissues. In order to better understand the pathophysiologic mechanisms involved, we developed a coarse-grained phenomenological model of the acute inflammatory response in CLP (cecal ligation...

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PMID: 22412365
DOI: 10.1371/journal.pcbi.1002422

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