Article

Sepsis Reconsidered: Identifying novel metrics for behavioral landscape characterization with a high-performance computing implementation of an agent-based model

2017-05-24

Abstract excerpt

<h4>Objectives: </h4> Sepsis affects nearly 1 million people in the United States per year, has a mortality rate of 28–50m% and requires more than $20 billion a year in hospital costs. Over a quarter century of research has not yielded a single reliable diagnostic test or a directed therapeutic agent for sepsis. Central to this insufficiency is the fact that sepsis remains a clinical/physiological diagnosis repres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d49f441-821f-5182-9946-f89763cf2e58
DOI: 10.1101/141804

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sepsis Reconsidered: Identifying novel metrics for behavioral landscape characterization with a high-performance computing implementation of an agent-based modelDOI 10.1101/141804Read

Determining controllability of sepsis using genetic algorithms on a proxy agent-based model of systemic inflammationSemantic proximity Read

Ensemble Models of Neutrophil Trafficking in Severe SepsisSemantic proximity Read

Development and validation of a cellular host response test as an early diagnostic for sepsisSemantic proximity Read

Development and Validation of 72-Hour Fluid Balance Trajectory Subphenotypes and Prognosis in Sepsis: A Multicenter Cohort StudySemantic proximity Read

Genetic Algorithms for model refinement and rule discovery in a high-dimensional agent-based model of inflammationSemantic proximity Read

Multi-Organ Intervention State Space (MOISS): A Collision Geometry Framework for Quantifying Therapeutic Windows Across 10 Organ Systems in 301,470 ICU PatientsSemantic proximity Read

Nested Active Learning for Efficient Model Contextualization and Parameterization: Pathway to generating simulated populations using multi-scale computational modelsSemantic proximity Read

Development Process of a Clinical Decision Support System for Empiric Antibiotic Therapies in Sepsis PatientsSemantic proximity Read

Therapeutic Distance: An Orbit-Based Framework for ICU Decision Support Initial Validation in 11,627 Sepsis Patients from MIMIC-IVSemantic proximity Read

High-throughput cancer hypothesis testing with an integrated PhysiCell-EMEWS workflowSemantic proximity Read

In silico design of clinical trials: A method coming of ageSemantic proximity Read