Article
Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids.
Critical care (London, England) - 28 Nov 2019
Seymour Christopher W, Kerti Samantha J, Lewis Anthony J, Kennedy Jason, Brant Emily, Griepentrog John E, Zhang Xianghong, Angus Derek C, Chang Chung-Chou H, Rosengart Matthew R
Abstract excerpt
BACKGROUND: Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in animal models of sepsis. Using a biotelemetry-enhanced, murine cecal ligation and puncture (CLP) model, we determined phenotypes of polymicrobial sepsis prior to physiologic deterioration, and the association between phenotypes and outcome in a...
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