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Article

Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria.

PLoS genetics - 1 Oct 2015

Bershtein Shimon, Serohijos Adrian W R, Bhattacharyya Sanchari, Manhart Michael, Choi Jeong-Mo, Mu Wanmeng, Zhou Jingwen, Shakhnovich Eugene I

Abstract excerpt

Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular and cellular constraints on functional integration of the foreign genes are poorly understood. Here we performed inter-species replacement of the chromosomal folA gene, encoding an essential metabolic enzyme dihydrofolate reductase (DHFR), with orthologs from 35 other mesophilic bacteria. The orthologous inter-species...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26484862
DOI: 10.1371/journal.pgen.1005612
PMCID: PMC4618355

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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