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Article

Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship.

Cell reports - 28 Apr 2015

Bershtein Shimon, Choi Jeong-Mo, Bhattacharyya Sanchari, Budnik Bogdan, Shakhnovich Eugene

Abstract excerpt

Linking the molecular effects of mutations to fitness is central to understanding evolutionary dynamics. Here, we establish a quantitative relation between the global effect of mutations on the E. coli proteome and bacterial fitness. We created E. coli strains with specific destabilizing mutations in the chromosomal folA gene encoding dihydrofolate reductase (DHFR) and quantified the ensuing changes in the...

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Identifiers

PMID: 25892240
DOI: 10.1016/j.celrep.2015.03.051
PMCID: PMC4416983

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DHFR

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