Article
Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain.
Journal of neuroimmunology - 1 Jun 2010
Swaminathan Bhairavi, Matesanz Fuencisla, Cavanillas Mariá L, Alloza Iraide, Otaegui David, Olascoaga Javier, Cénit María C, de las Heras Virgina, Barcina María García, Arroyo Rafael, Alcina Antonio, Fernandez Oscar, Antigüedad Alfredo, Urcelay Elena, Vandenbroeck Koen
Abstract excerpt
A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of significance. In the present study, using a combined all-Spain collection of 2515 MS patients and 2942...
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