Article
Genetic modifiers of multiple sclerosis progression, severity and onset.
Clinical immunology (Orlando, Fla.) - 1 Jul 2017
Sadovnick A Dessa, Traboulsee Anthony L, Zhao Yinshan, Bernales Cecily Q, Encarnacion Mary, Ross Jay P, Yee Irene M, Criscuoli Maria G, Vilariño-Güell Carles
Abstract excerpt
The genetic contribution to clinical outcomes for multiple sclerosis (MS) has yet to be defined. We performed exome sequencing analysis in 100 MS patients presenting opposite extremes of clinical phenotype (discovery cohort), and genotyped variants of interest in 2016 MS patients (replication cohort). Linear and logistic regression analyses were used to identify significant associations with disease course,...
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