Article
Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia.
The Journal of clinical investigation - 1 Dec 2007
Tan Serena Y, Rosenthal Julie, Zhao Xiao-Qing, Francis Richard J, Chatterjee Bishwanath, Sabol Steven L, Linask Kaari L, Bracero Luciann, Connelly Patricia S, Daniels Mathew P, Yu Qing, Omran Heymut, Leatherbury Linda, Lo Cecilia W
Abstract excerpt
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder associated with ciliary defects and situs inversus totalis, the complete mirror image reversal of internal organ situs (positioning). A variable incidence of heterotaxy, or irregular organ situs, also has been reported in PCD patients, but it is not known whether this is elicited by the PCD-causing genetic lesion. We studied a mouse model of...
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