Article
Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression.
Breast cancer research : BCR - 9 Mar 2012
Liu Mohan, Wang Liewei, Bongartz Tim, Hawse John R, Markovic Svetomir N, Schaid Daniel J, Mushiroda Taisei, Kubo Michiaki, Nakamura Yusuke, Kamatani Naoyuki, Goss Paul E, Ingle James N, Weinshilboum Richard M
Abstract excerpt
INTRODUCTION: Arthralgias and myalgias are major side effects associated with aromatase inhibitor (AI) therapy of breast cancer. In a recent genome-wide association study, we identified SNPs - including one that created an estrogen response element near the 3' end of the T-cell leukemia 1A (TCL1A) gene - that were associated with musculoskeletal pain in women on adjuvant AI therapy for breast cancer. We also...
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