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Article

TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence.

The Journal of pharmacology and experimental therapeutics - 1 Jun 2018

Ho Ming-Fen, Lummertz da Rocha Edroaldo, Zhang Cheng, Ingle James N, Goss Paul E, Shepherd Lois E, Kubo Michiaki, Wang Liewei, Li Hu, Weinshilboum Richard M

Abstract excerpt

T-cell leukemia 1A (TCL1A) single-nucleotide polymorphisms (SNPs) have been associated with aromatase inhibitor-induced musculoskeletal adverse events. We previously demonstrated that TCL1A is inducible by estradiol (E2) and plays a critical role in the regulation of cytokines, chemokines, and Toll-like receptors in a TCL1A SNP genotype and estrogen-dependent fashion. Furthermore, TCLIA SNP-dependent expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29592948
DOI: 10.1124/jpet.118.247718
PMCID: PMC5954488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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