Article
Vitamin D Levels, Vitamin D Receptor Polymorphisms, and Inflammatory Cytokines in Aromatase Inhibitor-Induced Arthralgias: An Analysis of CCTG MA.27.
Clinical breast cancer - 1 Feb 2018
Niravath Polly, Chen Bingshu, Chapman Judy-Anne W, Agarwal Sandeep K, Welschhans Robert L, Bongartz Tim, Kalari Krishna R, Shepherd Lois E, Bartlett John, Pritchard Kathleen, Gelmon Karen, Hilsenbeck Susan G, Rimawi Mothaffar F, Osborne C Kent, Goss Paul E, Ingle James N
Abstract excerpt
BACKGROUND: Approximately half of women taking aromatase inhibitor (AI) therapy develop AI-induced arthralgia (AIA), and many might discontinue AI therapy because of the pain. Using plasma samples from the MA.27 study, we assessed several factors potentially associated with AIA. PATIENTS AND METHODS: MA.27 is a phase III adjuvant trial comparing 2 AIs, exemestane versus anastrozole. Within an 893-participant...
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