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ESR1 polymorphisms were associated with aromatase inhibitors induced musculoskeletal symptoms in breast cancer patients.

Breast cancer research and treatment - 18 Mar 2026

Jing Feng, Jiang Lingyun, Cao Yuling, Tian Maoting, Qiu Jiajia, Tang Lichen, Hu Yan

Abstract excerpt

PURPOSE: Aromatase Inhibitors Associated Musculoskeletal Symptoms (AIMSS) are common side effects among hormone receptor-positive breast cancer patients, significantly affecting patients' treatment adherence and quality of life. The individual genetic susceptibility mechanism underlying AIMSS was not well understood yet. This study aimed to validate the association between genetic polymorphisms and AIMSS among...

Topics

Humans
Female
Aromatase Inhibitors
Breast Neoplasms
Estrogen Receptor alpha
Middle Aged
Polymorphism, Single Nucleotide
Cross-Sectional Studies
Adult
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Musculoskeletal Diseases

Genotype

Quality of Life

Source

Identifiers

PMID: 41848880
DOI: 10.1007/s10549-026-07927-3

Genes

ESR1
CYP19A1
ESR2
TCL1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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