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Article

Functional variable number of tandem repeats variation in the promoter of proto-oncogene PTTG1IP is associated with risk of estrogen receptor-positive breast cancer.

Cancer science - 1 Jun 2012

Xiang Chan, Gao Haidong, Meng Lei, Qin Zhaoyu, Ma Rong, Liu Yang, Jiang Yan, Dang Chengxue, Jin Li, He Fuchu, Wang Haijian

Abstract excerpt

Genetic polymorphisms in the signalling pathway of estrogen receptor (ER) could modify the risk of breast cancer. A variable number of tandem repeats (VNTR) polymorphism in the promoter of PTTG1IP, pituitary tumor transforming gene binding factor targeted by estrogen receptor α (ERα) in endocrine neoplasia, has been shown to be functional, but its relevance to cancer etiology was unknown. We investigated its...

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Identifiers

PMID: 22404099
DOI: 10.1111/j.1349-7006.2012.02266.x
PMCID: PMC7685090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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