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Article

Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer.

Breast cancer research : BCR - 26 Jan 2011

Li Yuqing, Li Yi, Wedrén Sara, Li Guoliang, Charn Tze Howe, Desai Kartiki Vasant, Bonnard Carine, Czene Kamila, Humphreys Keith, Darabi Hatef, Einarsdóttir Kristjana, Heikkinen Tuomas, Aittomäki Kristiina, Blomqvist Carl, Chia Kee Seng, Nevanlinna Heli, Hall Per, Liu Edison T, Liu Jianjun

Abstract excerpt

INTRODUCTION: Given the role of estrogen in breast carcinogenesis and the modification of estrogen receptor (ER) activity by its biochemical cofactors, we hypothesize that genetic variation within ER cofactor genes alters cellular response to estrogen exposure and consequently modifies the risk for ER-positive breast cancer. METHODS: We genotyped 790 tagging SNPs within 60 ER cofactor genes in 1,257 cases and...

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Source

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Identifiers

PMID: 21269472
DOI: 10.1186/bcr2817
PMCID: PMC3109578

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer.PMID 21269472Read ↗

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