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Article

A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 2002

De Vivo Immaculata, Huggins Gordon S, Hankinson Susan E, Lescault Pamela J, Boezen Marike, Colditz Graham A, Hunter David J

Abstract excerpt

Excessive estrogen stimulation unopposed by progesterone strongly predisposes to endometrial cancer. Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose to endometrial cancer. We found six variable sites, including four polymorphisms in the hPR gene and five common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12218173
DOI: 10.1073/pnas.192172299
PMCID: PMC129433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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