Article
Analysis of the ERalpha germline PvuII marker in breast cancer risk.
Medical science monitor : international medical journal of experimental and clinical research - 1 Mar 2008
González-Mancha Rosario, Galán Jose Jorge, Crespo Carmen, Iglesias Pérez Luis, González-Perez Antonio, Morón Francisco Jesús, Moreno Nogueira José Andrés, Real Luis Miguel, Pascual Manuel Hidalgo, Ruiz Agustin, Royo Jose Luis
Abstract excerpt
BACKGROUND: Prolonged exposure to estrogens was found to be a risk factor for breast cancer. The molecular mechanism has been suggested to be the binding of estrogen receptors in mammary tissue, which promotes the proliferation of breast tissue. Different biomarkers mapping estrogen receptor alpha (ESR1) have been associated with breast cancer risk, although the size of the effect is not consistent among...
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