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Article

Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer.

PloS one - 1 Jan 2012

Tennis Meredith A, Vanscoyk Michelle M, Wilson Lora A, Kelley Nicole, Winn Robert A

Abstract excerpt

Wnt7a is known to be a tumor suppressor that is lost in NSCLC, but no mechanism of loss has been established. Methylation of promoter regions has been established as a common mechanism of loss of tumor suppressor expression in NSCLC. We previously demonstrated that loss of Wnt7a in non-transformed lung epithelial cell lines led to increased cell growth, altered 3-D culture growth, and increased migration. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22403725
DOI: 10.1371/journal.pone.0032921
PMCID: PMC3293913

Genes

DNMT1

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