Article
DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.
Oncogene - 24 Jul 2003
Soejima Kenzo, Fang Weizhao, Rollins Barrett J
Abstract excerpt
Transcriptional silencing of tumor suppressor genes in association with DNA methylation contributes to malignant transformation. However, the specific DNA methyltransferases that initiate this process are unknown. Here we show that a de novo DNA methyltransferase, DNMT3b, substantially contribute...
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