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Article

Wif1 hypermethylation as unfavorable prognosis of non-small cell lung cancers with EGFR mutation.

Molecules and cells - 1 Jul 2013

Lee Su Man, Park Jae Yong, Kim Dong Sun

Abstract excerpt

Lung cancer is a leading cause of cancer-related mortality across the world and tobacco smoking is the major risk factor. The Wnt signaling pathway is known to be involved in smoke-induced tumorigenesis in the lung. Promoter hypermethylation of Wnt inhibitory factor 1 (Wif1) has become a common event in a number of human tumors. Using a methylation-specific PCR, hypermethylation of the Wif1 gene promoter was...

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Share to Adaptor Proteins, Signal Transducing
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to ErbB Receptors

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 23686431
DOI: 10.1007/s10059-013-0060-7
PMCID: PMC3887922

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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