Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.

Abstract excerpt

The ectopic expression of DNA methyltransferase 1 (DNMT 1) can transforms mammalian cells, and the inhibition of DNMT1 activity reverses that phenotypic transformation. Therefore, DNMT1 is considered to be an excellent target for therapeutic intervention. Previously, inhibition of DNMT1 was accomplished by using an antagonist or by antisense oligonucleotides. In this study, we examined the ability of the novel...

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