Article
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Cancer research - 1 Nov 2003
Belinsky Steven A, Klinge Donna M, Stidley Christine A, Issa Jean-Pierre, Herman James G, March Thomas H, Baylin Stephen B
Abstract excerpt
Disruption of one allele for the cytosine-DNA methyltransferase 1 (DNMT1) gene in mice with a germ-line mutation in a tumor suppressor gene was shown previously to reduce tumor formation in juvenile animals. This effect is now reproduced in our studies of mature mice where this genetic DNMT1 reduction leads to a 50% decrease in tobacco carcinogen-induced lung cancer and a similar reduction in DNMT activity in...
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