Article
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Nature genetics - 1 Sept 2008
Yasuda Kazuki, Miyake Kazuaki, Horikawa Yukio, Hara Kazuo, Osawa Haruhiko, Furuta Hiroto, Hirota Yushi, Mori Hiroyuki, Jonsson Anna, Sato Yoshifumi, Yamagata Kazuya, Hinokio Yoshinori, Wang He-Yao, Tanahashi Toshihito, Nakamura Naoto, Oka Yoshitomo, Iwasaki Naoko, Iwamoto Yasuhiko, Yamada Yuichiro, Seino Yutaka, Maegawa Hiroshi, Kashiwagi Atsunori, Takeda Jun, Maeda Eiichi, Shin Hyoung Doo, Cho Young Min, Park Kyong Soo, Lee Hong Kyu, Ng Maggie C Y, Ma Ronald C W, So Wing-Yee, Chan Juliana C N, Lyssenko Valeriya, Tuomi Tiinamaija, Nilsson Peter, Groop Leif, Kamatani Naoyuki, Sekine Akihiro, Nakamura Yusuke, Yamamoto Ken, Yoshida Teruhiko, Tokunaga Katsushi, Itakura Mitsuo, Makino Hideichi, Nanjo Kishio, Kadowaki Takashi, Kasuga Masato
Abstract excerpt
We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs22378...
Read the complete abstract on PubMed