SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.

doi:10.1038/ng.208

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Article

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.

Nature genetics - 1 Sept 2008

Unoki Hiroyuki, Takahashi Atsushi, Kawaguchi Takahisa, Hara Kazuo, Horikoshi Momoko, Andersen Gitte, Ng Daniel P K, Holmkvist Johan, Borch-Johnsen Knut, Jørgensen Torben, Sandbaek Annelli, Lauritzen Torsten, Hansen Torben, Nurbaya Siti, Tsunoda Tatsuhiko, Kubo Michiaki, Babazono Tetsuya, Hirose Hiroshi, Hayashi Matsuhiko, Iwamoto Yasuhiko, Kashiwagi Atsunori, Kaku Kohei, Kawamori Ryuzo, Tai E Shyong, Pedersen Oluf, Kamatani Naoyuki, Kadowaki Takashi, Kikkawa Ryuichi, Nakamura Yusuke, Maeda Shiro

Abstract excerpt

We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent...

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Asian People
Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Diabetes Mellitus, Type 2

Gene Expression

Genome-Wide Association Study

KCNQ1 Potassium Channel

Singapore

White People

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Open in PubMed

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PMID: 18711366
DOI: 10.1038/ng.208

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KCNQ1

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