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Article

The myotubularin family: from genetic disease to phosphoinositide metabolism.

Trends in genetics : TIG - 1 Apr 2001

Laporte J, Blondeau F, Buj-Bello A, Mandel J L

Abstract excerpt

The myotubularin-related genes define a large family of eukaryotic proteins, most of them initially characterized by the presence of a ten-amino acid consensus sequence related to the active sites of tyrosine phosphatases, dual-specificity protein phosphatases and the lipid phosphatase PTEN. Myotubularin (hMTM1), the founder member, is mutated in myotubular myopathy, and a close homolog (hMTMR2) was recently...

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Topics

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Share to Conserved Sequence
Share to Evolution, Molecular
Share to Myopathies, Structural, Congenital

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Phosphatidylinositols

Share to Protein Structure, Tertiary

Share to Protein Tyrosine Phosphatases

Share to Protein Tyrosine Phosphatases, Non-Receptor

Source

Identifiers

PMID: 11275328
DOI: 10.1016/s0168-9525(01)02245-4

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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