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Article

Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease.

Neurobiology of aging - 1 Nov 2013

Darreh-Shori Taher, Vijayaraghavan Swetha, Aeinehband Shahin, Piehl Fredrik, Lindblom Rickard P F, Nilsson Bo, Ekdahl Kristina N, Långström Bengt, Almkvist Ove, Nordberg Agneta

Abstract excerpt

Butyrylcholinesterase (BuChE) activity is associated with activated astrocytes in Alzheimer's disease brain. The BuChE-K variant exhibits 30%-60% reduced acetylcholine (ACh) hydrolyzing capacity. Considering the increasing evidence of an immune-regulatory role of ACh, we investigated if genetic heterogeneity in BuChE affects cerebrospinal fluid (CSF) biomarkers of inflammation and cholinoceptive glial function....

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Identifiers

PMID: 23759148
DOI: 10.1016/j.neurobiolaging.2013.04.027

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BCHE
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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