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Article

High-throughput genotyping of advanced congenic lines by high resolution melting analysis for identification of Bbaa2, a QTL controlling Lyme arthritis.

BioTechniques - 1 Mar 2012

Bramwell Kenneth K C, Ma Ying, Weis John H, Teuscher Cory, Weis Janis J

Abstract excerpt

Congenic mapping is a powerful strategy to identify genomic loci regulating quantitative traits. Generating congenic lines is an iterative process of refinement that is both time and resource intensive. Here we report an alternative to traditional microsatellite marker analysis or costly high-density oligonucleotide single nucleotide polymorphism (SNP) arrays for congenic genotyping. The identification of...

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Identifiers

PMID: 22401552
DOI: 10.2144/000113838
PMCID: PMC3329127

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