Article
A new mouse SNP genotyping assay for speed congenics: combining flexibility, affordability, and power.
BMC genomics - 24 May 2021
Andrews Kimberly R, Hunter Samuel S, Torrevillas Brandi K, Céspedes Nora, Garrison Sarah M, Strickland Jessica, Wagers Delaney, Hansten Gretchen, New Daniel D, Fagnan Matthew W, Luckhart Shirley
Abstract excerpt
BACKGROUND: Speed congenics is an important tool for creating congenic mice to investigate gene functions, but current SNP genotyping methods for speed congenics are expensive. These methods usually rely on chip or array technologies, and a different assay must be developed for each backcross strain combination. "Next generation" high throughput DNA sequencing technologies have the potential to decrease cost and...
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