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Article

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.

Traffic (Copenhagen, Denmark) - 1 Nov 2004

Ulloa-Aguirre Alfredo, Janovick Jo Ann, Brothers Shaun P, Conn P Michael

Abstract excerpt

The process of quality control in the endoplasmic reticulum involves a variety of mechanisms which ensure that only correctly folded proteins enter the secretory pathway. Among these are conformation-screening mechanisms performed by molecular chaperones that assist in protein folding and prevent non-native (or misfolded) proteins from interacting with other misfolded proteins. Chaperones play a central role in...

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PMID: 15479448
DOI: 10.1111/j.1600-0854.2004.00232.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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