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Article

Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53.

Human molecular genetics - 15 Jun 2016

Kim Sun-Hong, Shahani Neelam, Bae Byoung-Ii, Sbodio Juan I, Chung Youjin, Nakaso Kazuhiro, Paul Bindu D, Sawa Akira

Abstract excerpt

p53 has been implicated in the pathophysiology of Huntington's disease (HD). Nonetheless, the molecular mechanism of how p53 may play a unique role in the pathology remains elusive. To address this question at the molecular and cellular biology levels, we initially screened differentially expressed molecules specifically dependent on p53 in a HD animal model. Among the candidate molecules, wild-type p53-induced...

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Identifiers

PMID: 27206983
DOI: 10.1093/hmg/ddw115
PMCID: PMC6086561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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