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Article

Functional analysis of the Huntington's disease (HD) gene promoter

1 May 1998

Abstract excerpt

The basis for the highly specific neuronal vulnerability seen in Huntington's disease (HD) has not been determined. Recent studies have demonstrated that variation in HD protein expression occurs in the striatum, with affected regions showing increased HD immunoreactivity. Experiments in HD and SCA1 transgenic mice suggest a correlation between phenotypic severity and expression of the mutant transgene. To gain...

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PMID: 9536082
DOI: 10.1093/hmg/7.5.791

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