Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety.

doi:10.1016/j.pnpbp.2012.08.008

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Article

Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2013

Gajewska Agnieszka, Blumenthal Terry D, Winter Bernward, Herrmann Martin J, Conzelmann Annette, Mühlberger Andreas, Warrings Bodo, Jacob Christian, Arolt Volker, Reif Andreas, Zwanzger Peter, Pauli Paul, Deckert Jürgen, Domschke Katharina

Abstract excerpt

The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits. In 114 healthy individuals (males=57, females=57) controlled for anxiety sensitivity (AS), a multi-level risk model of the...

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PMID: 22940476
DOI: 10.1016/j.pnpbp.2012.08.008

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